Danny (Alejandro La Rosa) is your average Brooklyn party boy. This year, he and his friends couldn't be more excited about the upcoming "Brooklyn Annual Enema Party"; one of Brooklyn's biggest parties, the event is a place "where you come to get douched and dance". While the night starts out fun, it quickly takes a turn for the worst when Danny is attacked by a stranger. In the end, his fabulous drag queen and queer friends are able to save his life, but not without deadly consequences.
A year later, Danny is still going through the aftermath of that horrible incident and refuses to go to this year's upcoming party, despite the pressure of his close friends Cholata, Collin and Gayson. His friends want Danny to face his fears and go back out into the world. Danny refuses, but when a new boy, PuppyPup (José D. Álvarez) enters his life, Danny decides to give his social life and the Brooklyn nightlife scene a second chance. It isn't until his friends start to disappear and get killed in gruesome ways that Danny realises that his life, and everyone else who helped him that night, are in danger.